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KMID : 0043320190420010001
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Archives of Pharmacal Research
2019 Volume.42 No. 1 p.1 ~ p.13
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Tumor endothelial cells as a potential target of metronomic chemotherapy
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Kim Ji-Yoon
Kim Young-Myeong
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Abstract
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Drug resistance and toxic side effects are major therapeutic hurdles affecting cancer patients receiving conventional chemotherapy based on the maximum tolerated dose. Metronomic chemotherapy (MCT), a new therapeutic approach developed to avoid these problems generally, consists of the continuous administration of low-dose cytotoxic agents without extended intervals. This therapy targets the tumor microenvironment, rather than exerting a direct effect on tumor cells. As a result, the MCT regimen functionally impairs tumor endothelial cells and circulating endothelial progenitor cells, leading to tumor dormancy via anti-angiogenesis. Over the past 10 years, several studies have highlighted the impact of MCT on the tumor microenvironment and angiogenesis and demonstrated its potential as a switch from the pro-angiogenic to the anti-angiogenic state. However, the mechanisms of action are still obscure. Here, we systematically review the evidence regarding the anti-angiogenic potential of MCT as a crucial determinant of tumor dormancy and cancer treatment.
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KEYWORD
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Tumor, Metronomic chemotherapy, Endothelial cells, Angiogenesis, Vessel normalization
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